' 
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.4
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
Folic acid reduces hot flashes
The effect of folic Acid on menopausal hot flashes: a randomized clinical trial.
Highly relevant to folic acid impact
We investigated how folic acid might help with menopausal hot flashes, a common and often uncomfortable experience for many women. In our study, we enrolled 70 menopausal women and divided them randomly into two groups. One group received folic acid tablets, while the other group received a placebo for four weeks. This method allowed us to closely monitor the effects of folic acid against a control.
Throughout the study, we collected information using questionnaires, interviews, and hot flash diaries to track the severity, duration, and frequency of hot flashes. Our analysis revealed significant differences in hot flash experiences before and after treatment in both groups. Most notably, the group taking folic acid showed a reduction in mean severity and frequency of hot flashes during the second, third, and fourth weeks of treatment.
Given these findings, we concluded that folic acid effectively alleviates the challenging symptoms of hot flashes. This treatment alternative may be a promising option for women seeking relief, offering an affordable and accessible change in their daily health regimen.
Throughout the study, we collected information using questionnaires, interviews, and hot flash diaries to track the severity, duration, and frequency of hot flashes. Our analysis revealed significant differences in hot flash experiences before and after treatment in both groups. Most notably, the group taking folic acid showed a reduction in mean severity and frequency of hot flashes during the second, third, and fourth weeks of treatment.
Given these findings, we concluded that folic acid effectively alleviates the challenging symptoms of hot flashes. This treatment alternative may be a promising option for women seeking relief, offering an affordable and accessible change in their daily health regimen.
Read More
4
Folic acid ineffective for hot flashes
Folic acid supplementation in postmenopausal women with hot flushes: phase III randomised double-blind placebo-controlled trial.
Directly addresses folate's effect
We conducted a thorough investigation to see if folic acid could ease hot flashes for postmenopausal women. The study involved 164 participants, all experiencing at least 50 hot flushes a week. To ensure accurate results, we used a double-blind, placebo-controlled method, meaning neither the participants nor the researchers knew who received the folic acid or the placebo during the trial.
Over a period of 12 weeks, participants took either a daily 5 mg folic acid tablet or a placebo. They kept track of their hot flushes using a diary and filled out quality of life assessments at regular intervals. By the study's conclusion, we found no significant difference in the reduction of hot flush scores between the folic acid and placebo groups. The average decrease in hot flush scores was slightly better in the folic acid group but wasn't statistically significant.
Although we observed some potential benefits in quality of life scores for the folic acid group at the 8-week mark, particularly regarding emotional well-being, these findings do not conclusively prove that folic acid significantly alleviates hot flashes. Therefore, while there may be some positive effects worth exploring further, our study does not provide strong evidence that folic acid is effective in treating hot flashes for postmenopausal women.
Over a period of 12 weeks, participants took either a daily 5 mg folic acid tablet or a placebo. They kept track of their hot flushes using a diary and filled out quality of life assessments at regular intervals. By the study's conclusion, we found no significant difference in the reduction of hot flush scores between the folic acid and placebo groups. The average decrease in hot flush scores was slightly better in the folic acid group but wasn't statistically significant.
Although we observed some potential benefits in quality of life scores for the folic acid group at the 8-week mark, particularly regarding emotional well-being, these findings do not conclusively prove that folic acid significantly alleviates hot flashes. Therefore, while there may be some positive effects worth exploring further, our study does not provide strong evidence that folic acid is effective in treating hot flashes for postmenopausal women.
Read More
8
Folic acid may reduce hot flushes
Folic acid supplementation may cure hot flushes in postmenopausal women: a prospective cohort study.
Highly relevant to treatment effects
We examined the impact of folic acid supplementation on hot flushes in postmenopausal women as part of a controlled study. A total of forty-six women participated, divided evenly into two groups: one received a daily dose of folic acid (5 mg) for four weeks, while the other group received a placebo. Notably, four women from the placebo group dropped out during the study, which we took into account in our analysis.
The findings were promising. The group taking folic acid reported significantly more improvements in their hot flush symptoms compared to the placebo group. Additionally, we measured levels of 3-methoxy 4-hydroxy phenyl glycol (MHPG), a key player linked to the neurotransmitter norepinephrine. The treatment group showed a noteworthy drop in MHPG levels, suggesting that folic acid may help by reducing central norepinephrine activity, which seems to be connected to the hot flush experience.
In summary, our results indicate that folic acid could indeed offer a subjective benefit for managing hot flushes by affecting key neurological processes. This opens the door to considering folic acid supplementation as a potential option for relief in postmenopausal women facing this common issue.
The findings were promising. The group taking folic acid reported significantly more improvements in their hot flush symptoms compared to the placebo group. Additionally, we measured levels of 3-methoxy 4-hydroxy phenyl glycol (MHPG), a key player linked to the neurotransmitter norepinephrine. The treatment group showed a noteworthy drop in MHPG levels, suggesting that folic acid may help by reducing central norepinephrine activity, which seems to be connected to the hot flush experience.
In summary, our results indicate that folic acid could indeed offer a subjective benefit for managing hot flushes by affecting key neurological processes. This opens the door to considering folic acid supplementation as a potential option for relief in postmenopausal women facing this common issue.
Read More
Most Useful Reviews
8.8
Effective for hot flashes
Effective and reasonably priced Folate. I use this product for hot flashes even though I've passed menopause. I believe my medications might be causing the hot flashes. It has proven very effective; when I ran out, they reappeared! The cost is reasonable, so I'm pleased. Additionally, I had read that one should take Folate, not folic acid.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.4
- All Researches
9
Folic acid reduces hot flashes
The effect of folic Acid on menopausal hot flashes: a randomized clinical trial.
Highly relevant to folic acid impact
We investigated how folic acid might help with menopausal hot flashes, a common and often uncomfortable experience for many women. In our study, we enrolled 70 menopausal women and divided them randomly into two groups. One group received folic acid tablets, while the other group received a placebo for four weeks. This method allowed us to closely monitor the effects of folic acid against a control.
Throughout the study, we collected information using questionnaires, interviews, and hot flash diaries to track the severity, duration, and frequency of hot flashes. Our analysis revealed significant differences in hot flash experiences before and after treatment in both groups. Most notably, the group taking folic acid showed a reduction in mean severity and frequency of hot flashes during the second, third, and fourth weeks of treatment.
Given these findings, we concluded that folic acid effectively alleviates the challenging symptoms of hot flashes. This treatment alternative may be a promising option for women seeking relief, offering an affordable and accessible change in their daily health regimen.
Throughout the study, we collected information using questionnaires, interviews, and hot flash diaries to track the severity, duration, and frequency of hot flashes. Our analysis revealed significant differences in hot flash experiences before and after treatment in both groups. Most notably, the group taking folic acid showed a reduction in mean severity and frequency of hot flashes during the second, third, and fourth weeks of treatment.
Given these findings, we concluded that folic acid effectively alleviates the challenging symptoms of hot flashes. This treatment alternative may be a promising option for women seeking relief, offering an affordable and accessible change in their daily health regimen.
Read More
8
Folic acid may reduce hot flushes
Folic acid supplementation may cure hot flushes in postmenopausal women: a prospective cohort study.
Highly relevant to treatment effects
We examined the impact of folic acid supplementation on hot flushes in postmenopausal women as part of a controlled study. A total of forty-six women participated, divided evenly into two groups: one received a daily dose of folic acid (5 mg) for four weeks, while the other group received a placebo. Notably, four women from the placebo group dropped out during the study, which we took into account in our analysis.
The findings were promising. The group taking folic acid reported significantly more improvements in their hot flush symptoms compared to the placebo group. Additionally, we measured levels of 3-methoxy 4-hydroxy phenyl glycol (MHPG), a key player linked to the neurotransmitter norepinephrine. The treatment group showed a noteworthy drop in MHPG levels, suggesting that folic acid may help by reducing central norepinephrine activity, which seems to be connected to the hot flush experience.
In summary, our results indicate that folic acid could indeed offer a subjective benefit for managing hot flushes by affecting key neurological processes. This opens the door to considering folic acid supplementation as a potential option for relief in postmenopausal women facing this common issue.
The findings were promising. The group taking folic acid reported significantly more improvements in their hot flush symptoms compared to the placebo group. Additionally, we measured levels of 3-methoxy 4-hydroxy phenyl glycol (MHPG), a key player linked to the neurotransmitter norepinephrine. The treatment group showed a noteworthy drop in MHPG levels, suggesting that folic acid may help by reducing central norepinephrine activity, which seems to be connected to the hot flush experience.
In summary, our results indicate that folic acid could indeed offer a subjective benefit for managing hot flushes by affecting key neurological processes. This opens the door to considering folic acid supplementation as a potential option for relief in postmenopausal women facing this common issue.
Read More
7
Folic acid may reduce hot flashes
Folic acid supplementation cures hot flushes in postmenopausal women.
Study relevance is moderately significant
We explored whether folic acid supplementation could help alleviate hot flashes in postmenopausal women. The study highlighted that hot flashes often stem from changes in the body’s temperature control system, primarily due to decreased estrogen levels. This hormonal shift leads to increased activity of certain brain chemicals, specifically norepinephrine, and decreased levels of serotonin.
Our hypothesis was that folic acid might help ease these symptoms by interacting with the same brain chemicals that estrogen does. Over the years, research has shown that folic acid can produce an antidepressant-like effect, affecting both noradrenergic and serotonergic receptors in the brain. This raises the intriguing possibility that it could offer a similar benefit when it comes to managing hot flashes, although the specific effectiveness of folate on this issue is still under investigation.
While preliminary data supports our ideas, more research is needed to draw firm conclusions. It’s exciting to consider the potential of folic acid as a natural remedy for hot flashes, but we must proceed with caution until further evidence is available.
Our hypothesis was that folic acid might help ease these symptoms by interacting with the same brain chemicals that estrogen does. Over the years, research has shown that folic acid can produce an antidepressant-like effect, affecting both noradrenergic and serotonergic receptors in the brain. This raises the intriguing possibility that it could offer a similar benefit when it comes to managing hot flashes, although the specific effectiveness of folate on this issue is still under investigation.
While preliminary data supports our ideas, more research is needed to draw firm conclusions. It’s exciting to consider the potential of folic acid as a natural remedy for hot flashes, but we must proceed with caution until further evidence is available.
Read More
4
Folic acid ineffective for hot flashes
Folic acid supplementation in postmenopausal women with hot flushes: phase III randomised double-blind placebo-controlled trial.
Directly addresses folate's effect
We conducted a thorough investigation to see if folic acid could ease hot flashes for postmenopausal women. The study involved 164 participants, all experiencing at least 50 hot flushes a week. To ensure accurate results, we used a double-blind, placebo-controlled method, meaning neither the participants nor the researchers knew who received the folic acid or the placebo during the trial.
Over a period of 12 weeks, participants took either a daily 5 mg folic acid tablet or a placebo. They kept track of their hot flushes using a diary and filled out quality of life assessments at regular intervals. By the study's conclusion, we found no significant difference in the reduction of hot flush scores between the folic acid and placebo groups. The average decrease in hot flush scores was slightly better in the folic acid group but wasn't statistically significant.
Although we observed some potential benefits in quality of life scores for the folic acid group at the 8-week mark, particularly regarding emotional well-being, these findings do not conclusively prove that folic acid significantly alleviates hot flashes. Therefore, while there may be some positive effects worth exploring further, our study does not provide strong evidence that folic acid is effective in treating hot flashes for postmenopausal women.
Over a period of 12 weeks, participants took either a daily 5 mg folic acid tablet or a placebo. They kept track of their hot flushes using a diary and filled out quality of life assessments at regular intervals. By the study's conclusion, we found no significant difference in the reduction of hot flush scores between the folic acid and placebo groups. The average decrease in hot flush scores was slightly better in the folic acid group but wasn't statistically significant.
Although we observed some potential benefits in quality of life scores for the folic acid group at the 8-week mark, particularly regarding emotional well-being, these findings do not conclusively prove that folic acid significantly alleviates hot flashes. Therefore, while there may be some positive effects worth exploring further, our study does not provide strong evidence that folic acid is effective in treating hot flashes for postmenopausal women.
Read More
4
No significant impact from folate
Effect of L-methionine on hot flashes in postmenopausal women: a randomized controlled trial.
Relevance due to mixed results
We investigated the effects of folate in a study that included 51 postmenopausal women experiencing significant hot flashes. These women were carefully divided into groups: some received L-methionine, while others received a placebo, all while taking folate and methylcobalamin. The aim was to determine if folate could help alleviate the discomfort of hot flashes.
Despite the thoughtful setup and monitoring of participants, the results revealed no significant benefit of L-methionine for reducing hot flashes in comparison to the placebo group. We noted that both groups showed a decrease in hot flash frequency, but not enough to claim that folate had any positive effect.
It is important to highlight that folate was administered alongside L-methionine, making it challenging to isolate its potential impact on hot flashes. Consequently, while we explored its role, the findings suggest that folate alone might not play a significant part in managing this symptom for postmenopausal women.
Despite the thoughtful setup and monitoring of participants, the results revealed no significant benefit of L-methionine for reducing hot flashes in comparison to the placebo group. We noted that both groups showed a decrease in hot flash frequency, but not enough to claim that folate had any positive effect.
It is important to highlight that folate was administered alongside L-methionine, making it challenging to isolate its potential impact on hot flashes. Consequently, while we explored its role, the findings suggest that folate alone might not play a significant part in managing this symptom for postmenopausal women.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Effective for hot flashes
Effective and reasonably priced Folate. I use this product for hot flashes even though I've passed menopause. I believe my medications might be causing the hot flashes. It has proven very effective; when I ran out, they reappeared! The cost is reasonable, so I'm pleased. Additionally, I had read that one should take Folate, not folic acid.
Read More
